Channeling into the Epilepsies
نویسندگان
چکیده
منابع مشابه
Physiologic alterations in ataxia: channeling changes into novel therapies.
The ataxias constitute a heterogeneous group of diseases in which cerebellar dysfunction typically underlies the major neurologic manifestations. It is increasingly clear that ataxia can result directly from mutations in ion channels or from perturbations in ion channel physiology in the absence of a primary channel defect. Neuronal dysfunction stemming from perturbed channel activity likely ex...
متن کاملChanneling to the Nucleus
L-type voltage-gated calcium channels (LTCs) may control neuronal gene expression by increasing nuclear Ca(2+) levels or regulating Ca(2+)/calmodulin-dependent transcription factors. In the November 3 issue of Cell, Gomez-Ospina et al. demonstrate another signaling mechanism, in which a C-terminal fragment of LTC translocates to the nucleus in a calcium-dependent manner and directly regulates t...
متن کاملThe genetics of epilepsies.
OBJECTIVES To discuss some of the clinical and molecular genetic aspects of new discoveries in the field of the genetics of the epilepsies and relate these with relevant clues for a better understanding of the mechanisms underlying some of the monogenic epilepsy syndromes. SOURCES Many study designs have been performed over the years and these include family-based studies, genetic-epidemiolog...
متن کاملThe Epilepsies in Childhood.
A convulsion or major fit is a sudden outburst of motor spasm, or involuntary movement, of the whole or of part of the body, usually associated with loss of consciousness. In a minor fit there is a loss or dimming of consciousness without muscular twitching. The mechanism immediately responsible for the fit is generally accepted to be an excessive discharge of cortical neurones, in a state of p...
متن کاملNeuroimaging of the epilepsies
The superiority of magnetic resonance imaging (MRI) over X-ray computed tomography (CT) scanning in terms of sensitivity and specificity for identifying the aetiology of epilepsy in both adults and children is firmly established. The most common abnormalities identified are hippocampal sclerosis (HS), malformations of cortical development (MCD), vascular malformations, tumours, and acquired cor...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Epilepsy Currents
سال: 2008
ISSN: 1535-7597,1535-7511
DOI: 10.1111/j.1535-7511.2008.00229.x